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Lacticaseibacillus rhamnosus may help in periodontal disease

A new study explores how a specific probiotic, Lacticaseibacillus rhamnosus GG (LGG),
might help improve the regeneration of bones in the gums affected by periodontal disease, especially in the presence of high cholesterol levels (hyperlipidemia). 

Periodontal disease can lead to the loss of bone in the jaw, making it challenging for the bone to regenerate.

The researchers used a rat model with conditions mimicking periodontal disease, high cholesterol, and a defect in the gums. The rats were given LGG for six weeks, and then various measurements were taken after sacrificing the rats to understand the effects.

They found that the bone density, volume, and thickness in the affected area increased after the rats were given LGG. 

Interestingly, these improvements were not due to direct effects on the oral bacteria but were linked to changes in the gut microbiota. 

When fecal matter containing the altered gut bacteria from LGG-treated rats was transplanted into other rats, similar improvements in bone regeneration were observed.

The study also investigated the changes in blood metabolites (substances produced during metabolism) after LGG administration. One particular metabolite, selenomethionine, was found to promote the formation of bone cells in laboratory experiments. This substance was also associated with the key bacteria in the gut affected by LGG.

In summary, the research suggests that LGG, a probiotic, may enhance the regeneration of bone in the gums during periodontal disease, especially in the presence of high cholesterol. 

This improvement appears to be linked to changes in the gut microbiota and increased levels of specific blood metabolites that support bone formation. The findings provide new insights into how probiotics might be used to boost the recovery of bone in the gums through a complex interaction between the gut, blood, and bone.

Source:

Huang Y, Ge R, Qian J, Lu J, Qiao D, Chen R, Jiang H, Cui D, Zhang T, Wang N, He S, Wang M, Yan F. Lacticaseibacillus rhamnosus GG Improves Periodontal Bone Repair via Gut-Blood Axis in Hyperlipidemia. J Dent Res. 2024 Jan 10:220345231217402. doi: 10.1177/00220345231217402. Epub ahead of print. PMID: 38197171.

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