Wellness-uptodate

A new study explores how a specific probiotic, Lacticaseibacillus rhamnosus GG (LGG), might help improve the regeneration of bones in the gums affected by periodontal disease, especially in the presence of high cholesterol levels (hyperlipidemia).  Periodontal disease can lead to the loss of bone in the jaw, making it challenging for the bone to regenerate. The researchers used a rat model with conditions mimicking periodontal disease, high cholesterol, and a defect in the gums. The rats were given LGG for six weeks, and then various measurements were taken after sacrificing the rats to understand the effects. They found that the bone density, volume, and thickness in the affected area increased after the rats were given LGG.  Interestingly, these improvements were not due to direct effects on the oral bacteria but were linked to changes in the gut microbiota.  When fecal matter containing the altered gut bacteria from LGG-treated rats was transplanted into other rats, similar improvem