Wellness-uptodate

Researchers have conducted a study focusing on specific brain cells called GABRA5 neurons in the lateral hypothalamic area (LHA) of male rats to understand their role in managing obesity.  These neurons have connections to both white and brown fat tissues in the body.  When obese mice had their GABRA5 neurons suppressed, they experienced metabolic impairments and weight gain, whereas reducing the activity of an enzyme called MAO-B in nearby astrocytes led to increased fat burning and less weight gain.  This suggests that these neurons may help prevent fat accumulation, offering potential insights into obesity treatment strategies.  Additionally, brown adipose tissue (BAT) has been associated with lower risks of cardiometabolic diseases, and a drug called KDS2010, which inhibits MAO-B, has shown promise in promoting weight loss and is in Phase 1 clinical trials as a potential obesity treatment.  Read Original Article