Wellness-uptodate

A new study explores how a specific probiotic, Lacticaseibacillus rhamnosus GG (LGG), might help improve the regeneration of bones in the gums affected by periodontal disease, especially in the presence of high cholesterol levels (hyperlipidemia).  Periodontal disease can lead to the loss of bone in the jaw, making it challenging for the bone to regenerate. The researchers used a rat model with conditions mimicking periodontal disease, high cholesterol, and a defect in the gums. The rats were given LGG for six weeks, and then various measurements were taken after sacrificing the rats to understand the effects. They found that the bone density, volume, and thickness in the affected area increased after the rats were given LGG.  Interestingly, these improvements were not due to direct effects on the oral bacteria but were linked to changes in the gut microbiota.  When fecal matter containing the altered gut bacteria from LGG-treated rats was transplanted into other rats, si...

  Carbamate and Alzheimer Alzheimer's disease is a brain disorder that mostly affects older people. It gets worse over time and causes problems with memory and thinking. We still don't fully understand why Alzheimer's disease happens, but it seems to be caused by a lot of different things going wrong. There are some important signs that we often see in the brains of people with Alzheimer's. These include the loss of certain brain cells, the buildup of abnormal substances like plaques, problems with metals in the brain, changes in a protein called tau, too much stress inside brain cells, swelling and problems with the immune system in the brain, and issues with the energy centers in brain cells. Current treatments, right now, is based in some medicines that can help with the symptoms of Alzheimer's, but they don't fix the main problems in the brain.  These medicines are called donepezil, rivastigmine, galantamine, and memantine. There's a need for better drug...