Carbamate and AlzheimerAlzheimer's disease is a brain disorder that mostly affects older people. It gets worse over time and causes problems with memory and thinking.
We still don't fully understand why Alzheimer's disease happens, but it seems to be caused by a lot of different things going wrong.
There are some important signs that we often see in the brains of people with Alzheimer's. These include the loss of certain brain cells, the buildup of abnormal substances like plaques, problems with metals in the brain, changes in a protein called tau, too much stress inside brain cells, swelling and problems with the immune system in the brain, and issues with the energy centers in brain cells.
Current treatments, right now, is based in some medicines that can help with the symptoms of Alzheimer's, but they don't fix the main problems in the brain.
These medicines are called donepezil, rivastigmine, galantamine, and memantine.
There's a need for better drugs for Alzheimer's that can both improve the brain's health and help with the symptoms.
Scientists are looking into a specific type of drug called carbamate to treat Alzheimer's. Rivastigmine is one of these drugs.
It works by stopping a chemical called acetylcholinesterase, which is important for brain function.
Recent Research: In the last 10 years, researchers have been trying to make better carbamate drugs for Alzheimer's.
They're doing this by changing parts of the drug's structure so that it can do more things like stopping acetylcholinesterase, reducing stress in the brain, and preventing the buildup of abnormal substances.
In summary, Alzheimer's disease is a complicated brain condition that affects memory and thinking.
Current medicines help with symptoms but don't treat the main causes.
Scientists are working on new drugs called carbamates, like rivastigmine, to try and create better treatments for Alzheimer's by targeting various aspects of the disease.
ReferenceCarbamate as a potential anti-Alzheimer's pharmacophore: A review
Aging Memory and Oregano
Aging is a natural process where our bodies undergo various changes over time. Some of these changes can affect the normal functioning of our tissues.
Carvacrol is a compound that has gained attention in scientific research due to its wide range of potential health benefits. It is a natural compound found in various plants, particularly in oregano and thyme, and also responsible for the distinctive aroma and flavor of these herbs.
Carvacrol has garnered attention for its potential health benefits and is known for its antimicrobial, antioxidant, and anti-inflammatory properties.
In this a recent study aimed to investigate whether carvacrol could have a protective effect on aging in rats.
Experimental Setup: Old rats were chosen for the study, and they were given carvacrol in different doses (either 15 mg/kg or 30 mg/kg) every day for four weeks.
Memory Testing: To assess the effects of carvacrol, researchers conducted two tests on the rats to evaluate their memory and learning abilities. One test involved a maze (Morris water maze), and the other tested their ability to remember things (passive avoidance test).
Brain samples from the hippocampus and cortex of these rats were also collected for further analysis.
When compared to a group of young rats, the old rats that didn't receive carvacrol showed signs of memory and learning difficulties. However, the rats that received carvacrol performed better in the memory and learning tests.
The brains of the older rats had higher levels of a harmful substance called malondialdehyde (MDA) and lower levels of a beneficial compound known as total thiol groups when compared to the younger rats. But, when the older rats were given carvacrol, these imbalances improved.
It appears that carvacrol enhances memory in aging rats by reducing the levels of MDA (which is associated with cell damage) and increasing the levels of total thiol groups (which are protective molecules) in their brains.
In summary, this study found that carvacrol, a compound with potential health benefits, can improve memory and brain health in older rats. This suggests that carvacrol may have therapeutic potential for addressing age-related cognitive decline and brain issues, which could have broader implications for human health.
Reference
Lactobacillus and Diabetes
A recent study study looked at how a type of bacteria called Lactobacillus rhamnosus GG, which is known to be beneficial for the gut, could help prevent insulin resistance and type 2 diabetes in rats that were fed a diet that can make them obese and unhealthy.
They had two types of diets for the rats - a regular one and an unhealthy one that could lead to obesity and diabetes. Some rats got these diets alone, and some got them with either live Lactobacillus rhamnosus GG (the probiotic) or heat-inactivated Lactobacillus rhamnosus GG (parabiotic).
They found that both the probiotic and parabiotic treatments helped prevent the rats from gaining too much weight, which is common with the unhealthy diet. They also noticed that both treatments improved the rats' blood sugar levels and insulin levels, which are important for preventing diabetes.
Additionally, the treatments with either the probiotic or parabiotic helped balance certain hormones like adiponectin and leptin, which play a role in controlling body weight.
Interestingly, the parabiotic treatment was especially effective in reducing fat in the muscles and improving the way muscles use energy. This could be important for overall metabolic health.
In summary, the study suggests that the heat-inactivated form of Lactobacillus rhamnosus GG (parabiotic) may be more effective than the live probiotic in preventing insulin resistance and diabetes in rats fed an unhealthy diet.
This finding could have implications for potential treatments to address obesity-related health problems in humans.
Reference
.png)
Comments
Post a Comment