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A Closer Look at Selective Serotonin Reuptake Inhibitors (SSRIs) in Depression Treatment

  Decades ago, when people suffered from clinical depression, they were often given a group of antidepressants called tricyclic (TCAs) to help them feel better. These drugs had many and different side effects and weren’t safer than new drugs.  However, things changed when a new type of medication called selective serotonin reuptake inhibitors (SSRIs) came into widespread use. These SSRIs were much safer and easier for people to tolerate. But even though SSRIs were good news, they still have some limitations. They can sometimes make you feel more worried during the first days of the treatment.  It also takes a while for them to work and make you feel better. Some people taking SSRIs also experience problems with their sex drive, sleep, and the overall effectiveness of the treatment is not always very strong.  SSRIs may not work well for people who have symptoms like a lack of interest in things they used to enjoy and difficulties with thinking. There are other medicat...