Skip to main content

Brain health. Promising prebiotics and probiotics combination


According to new research, the bacteria in our gut, known as gut microbiota, play an important role in brain injury and healing after a stroke.

Taking particular types of prebiotics and probiotics can help with brain injury, inflammation, gut bacteria imbalances, and intestinal health.

However, we still don't know whether prebiotics, probiotics, or synbiotics (a combination of both) perform best for particular conditions, or how they operate.

In this study, scientists tested a new synbiotic formulation containing multiple strains of probiotics

  • Lactobacillus reuteri UBLRu-87
  • Lactobacillus plantarum UBLP-40
  • Lactobacillus rhamnosus UBLR-58
  • Lactobacillus salivarius UBLS-22
  • Bifidobacterium breve UBBr-01
  • and prebiotic fructooligosaccharides (FOS) 

FOS are extracted from the blue agave plant and fruits and vegetables such as bananas, onions, chicory root, garlic, asparagus, jícama, and leeks. Some grains and cereals, such as wheat and barley, also contain FOS. The Jerusalem artichoke and its relative yacón, together with the blue agave plant, have been found to have the highest concentrations of FOS of cultured plants. (See more)

They used a rat model of stroke called middle cerebral artery occlusion (MCAO).

Before producing a stroke, they gave the synbiotic to the rats for three weeks.

Three days after the stroke, the rats' sensory and motor abilities improved by the synbiotic treatment.

  • It halted the death of brain cells in the damaged area and
  • Diminished the extent of the stroke's brain damage.

The synbiotic therapy also

  • Restored the levels of proteins that support intestinal integrity
  • Reversed the elevated amounts of certain proteins and chemicals linked to brain inflammation and cell death.
  • Increased the abundance of good bacteria
  • Reduced harmful bacteria

Rats, not human beings, but these findings suggest that the new synbiotic preparation has the potential to improve neurological dysfunctions caused by stroke by influencing the communication between the gut and the brain in rats.

Source:

Rahman Z, Bhale NA, Dikundwar AG, Dandekar MP. Multistrain Probiotics with Fructooligosaccharides Improve Middle Cerebral Artery Occlusion-Driven Neurological Deficits by Revamping Microbiota-Gut-Brain Axis. Probiotics Antimicrob Proteins. 2023 Jun 26. doi: 10.1007/s12602–023–10109-y. Epub ahead of print. PMID: 37365420.

https://pubmed.ncbi.nlm.nih.gov/37365420/

Comments

Popular posts from this blog

Light Therapy holds promise as a treatment for Alzheimer's Disease

A new article, conducted by Lili Zang and colleagues from Weifang Medical University School of Nursing in Shandong Province, China, discusses a meta-analysis of 15 high-quality trials that investigated the impact of light therapy on individuals with Alzheimer’s disease (AD). The meta-analysis included 598 patients with mild to moderate Alzheimer’s disease, and it covered 15 randomized controlled trials conducted in seven different countries. Those trials were published between 2005 and 2022. Sleep Improvement Light therapy led to significant improvements in several sleep measures. It notably enhanced sleep efficiency, increased interdaily stability, and reduced intradaily variability, all of which are indicators of better sleep quality. Light therapy was associated with a reduction in agitation, depression, and caregiver burden among individuals with Alzheimer’s disease. A significant advantage over usual care was shown in reducing the severity of psychobehavioral symptoms, as assessed...

Los no fumadores engordan menos

Un nuevo estudio relaciona el tabaquismo con la ganancia de peso, y concluye que las personas fumadoras activas, no sólo las que lo dejan, engordan más que las no fumadoras. Después de cuatro años de análisis en la Universidad de Navarra, las personas que menos engordaron fueron las que nunca habían fumado.

Lacticaseibacillus rhamnosus may help in periodontal disease

A new study explores how a specific probiotic, Lacticaseibacillus rhamnosus GG (LGG), might help improve the regeneration of bones in the gums affected by periodontal disease, especially in the presence of high cholesterol levels (hyperlipidemia).  Periodontal disease can lead to the loss of bone in the jaw, making it challenging for the bone to regenerate. The researchers used a rat model with conditions mimicking periodontal disease, high cholesterol, and a defect in the gums. The rats were given LGG for six weeks, and then various measurements were taken after sacrificing the rats to understand the effects. They found that the bone density, volume, and thickness in the affected area increased after the rats were given LGG.  Interestingly, these improvements were not due to direct effects on the oral bacteria but were linked to changes in the gut microbiota.  When fecal matter containing the altered gut bacteria from LGG-treated rats was transplanted into other rats, si...