Descubren el proceso por el que los antidepresivos crean nuevas células cerebrales

Por primera vez en modelo humano, un equipo de investigadores del King's College de Londres ha descubierto cómo los antidepresivos permiten la aparición de nuevas células cerebrales.

DM - Miércoles, 13 de Abril de 2011 - Actualizado a las 00:00h.

El hallazgo, que se publica en el último número de Molecular Psychiatry, permitirá el desarrollo de nuevas y mejores opciones farmacológicas contra la depresión. Christoph Anacker, del Instituto de Psiquiatría del centro inglés, es el autor principal del trabajo.

Investigaciones previas habían determinado que el uso de antidepresivos conduce a la creación de nuevas células, pero hasta ahora no se sabía cómo. Los investigadores han definido que estos fármacos regulan el receptor de glucocorticoides, proteína relacionada con la respuesta al estrés. El estudio apunta, además, que todos los tipos de antidepresivos dependen de este receptor para crear nuevas células cerebrales.

Memoria alterada
Los afectados de depresión sufren una reducción en el proceso de neurogénesis, lo que facilita la aparición de síntomas depresivos como un estado de ánimo bajo y alteraciones en la memoria. Basándose en células madre del hipocampo humano, los investigadores han analizado in vitro los efectos de los antidepresivos en las células cerebrales.

Anacker desvela que han demostrado que los antidepresivos producen más células madre y que, además, aceleran su desarrollo hacia células cerebrales adultas. Asimismo, su equipo también ha demostrado que las hormonas ligadas al estrés, cuyos niveles están generalmente elevados en afectados de depresión, muestran el efecto contrario.

Contrarrestar el efecto
Las pruebas in vitro han revelado que los antidepresivos activan el receptor de glucocorticoides, que a su vez desencadena la activación de genes que convierten células madre inmaduras en células cerebrales adultas. Al incrementar el número de nuevas células en el cerebro, los antidepresivos contrarrestan los efectos dañinos de las hormonas ligadas al estrés y superan las alteraciones cerebrales que provocan el estado bajo de ánimo y los déficits en la memoria.
http://psiquiatria.diariomedico.com/2011/04/13/area-cientifica/especialidades/psiquiatria/descubren-proceso-por-que-antidepresivos-crean-nuevas-celulas-cerebrales

Comments

Nordic Walking Benefits, ADHD and Diet, Supplements and Cancer, Sources of Fiber

A Better Way To Walk: Nordic Walking Improves Quality of Life, Depression, and Functional Capacity SciTechDaily Reference: “Sustained Effects of Different Exercise Modalities on Physical and Mental Health in Patients With Coronary Artery Disease: A Randomized ... Dietary Interventions for ADHD: Emerging Research and Considerations There has been increasing interest in the role that diet and supplements play in the treatment of attention-deficit/hyperactivity disorder (ADHD) symptoms, from patients and researchers alike. Diet is an important treatment approach to consider, as it is a lifestyle change rather than a medication. Additionally, at least 10% to 30% of children with ADHD are non-responsive to, or experience adverse effects from, ADHD medications.1 A dietary approach to ADHD can be complementary to a conventional pharmacological approach, giving patients and their families more options toward a personalized treatment plan. This article will examine current research about di

More People Are Microdosing for Mental Health. But Does It Work?

By Dana G Smith. Joseph started microdosing psychedelics five years ago to try to improve his mental health. “I was just kind of in this depression, in this rut,” he said. “I was unhappy and angry and agitated all the time, and it went against the way that I saw myself.” Depression and anxiety run in Joseph’s family, and he’d been prescribed Prozac as a kid. But when symptoms of depression returned in his early 30s, he didn’t want to go back to a prescription drug. Joseph, an Austin-based designer (he asked to withhold his full name, citing privacy concerns surrounding mental health issues and illegal drug use), came across research from Johns Hopkins University about psilocybin, the active ingredient in hallucinogenic, or “magic,” mushrooms. In a small study, full doses of the drug helped cancer patients cope with depression and anxiety. Then he read anecdotes of Silicon Valley influencers claiming increased energy from taking tiny doses of psychedelics. So he decided to start microdo

Exploring the Link Between Circadian Rhythms, Longevity, and Wearable Data: Insights and Future Directions

A recent study in NHANES 2011–2014 explores the potential connection between disruptions in circadian rhythms, measured using wearable devices, and their impact on health outcomes and longevity. The study analyzes data from 7,297 U.S. adults collected through wearable accelerometers as a novel digital biomarker for longevity. Five distinct clusters were identified based on activity profiles: "High activity," "Low activity," "Mild circadian rhythm (CR) disruption," "Severe CR disruption," and "Very low activity." The findings reveal that young adults with extreme circadian rhythm disturbance exhibit higher white blood cell counts and accelerated biological aging. Older adults with circadian disruption are associated with increased systemic inflammation indexes, advanced biological aging, and higher all-cause mortality risk. The research underscores the importance of circadian alignment for longevity at all ages and suggests that wearable

Wellness-uptodate

Search This Blog