In a recent study, vaginal microbiome did not show any significant changes following orally administered probiotic

A longitudinal study of 16 healthy, Danish women in the reproductive age investigated whether lactobacilli, orally consumed, impacted the vaginal microbiome and its functional potential was published today in APMIS.

The 16 women aged 19-45 years were recruited from Copenhagen, Denmark. One baseline vaginal sample (day 0) and two other (day 25-30 and day 55-60, respectively) were sampled and were analyzed by "shotgun metagenomics", a method that allows researchers to sample all genes in all organisms present in a given complex sample.

Twenty-six species in the vaginal microbiota were detected, of which six belonged to the Lactobacillus genus.

Three vaginal microbiome clusters were mainly dominated by Gardnerella vaginalis, Lactobacillus iners or Lactobacillus crispatus.

Most of the subjects (11 out of 16 women) exhibited only minor changes in the vaginal microbiome during the treatment with probiotics. The oral probiotic had no detectable effect on either the composition or the functional potential of the vaginal microbiota.

Future studies may benefit from an increased number of participants, or administration of the probiotics during bacterial imbalance (e.g. during/after antibiotic treatment)

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