WUTD Today 5/25/2022 Anxiety. The bar ridiculously low, Metformin, Sick after Exercise, Diet makes a difference

'Set the bar ridiculously low': Rhik Samadder's golden rule for beating anxiety - The Guardian
The Guardian
Apart from CBT, the usual practical stuff works. Nutritious food, regular sleep and exercise; seeing friends, tidying up, doing things I'm good at.

Metformin, Lifestyle Interventions Can Prevent T2D, But Do Little for CVD Risk in Prediabetes
Using 21 years of follow-up data from more than 3000 patients with prediabetes, results of the DPPOS study demonstrate metformin use and lifestyle intervention reduced the risk of progressing to T2D, but did little to reduce the long-term risk of cardiovascular disease in these patients.

Feel Sick After Exercise? A Scientist Explains Why, And How to Prevent It - ScienceAlert
ScienceAlert
Many of us exercise to feel better. While some of us get "runners' highs" after a workout, unfortunately some of us leave the gym feeling nauseous ...

The overlooked variable in animal studies: why diet makes a difference - Nature
Nature
“Standard chow can be so many different things,” says team member Giada De Palma, a microbiome researcher at McMaster University in Hamilton, Canada.

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Exploring the Link Between Circadian Rhythms, Longevity, and Wearable Data: Insights and Future Directions

A recent study in NHANES 2011–2014 explores the potential connection between disruptions in circadian rhythms, measured using wearable devices, and their impact on health outcomes and longevity. The study analyzes data from 7,297 U.S. adults collected through wearable accelerometers as a novel digital biomarker for longevity. Five distinct clusters were identified based on activity profiles: "High activity," "Low activity," "Mild circadian rhythm (CR) disruption," "Severe CR disruption," and "Very low activity." The findings reveal that young adults with extreme circadian rhythm disturbance exhibit higher white blood cell counts and accelerated biological aging. Older adults with circadian disruption are associated with increased systemic inflammation indexes, advanced biological aging, and higher all-cause mortality risk. The research underscores the importance of circadian alignment for longevity at all ages and suggests that wearable

The safety of aspartame is under review by WHO after conflicting findings.

Aspartame, a sweetener with health effects Since 1981, the WHO expert committee on additives has confirmed the safety of aspartame consumption within acceptable daily limits. The international organization has established that the acceptable daily intake (ADI) of aspartame is 40 milligrams per kilogram of body weight. This means that a person can consume up to 40 mg of aspartame per kilogram of their body weight per day without risking their health. For example, if someone weighs 60 kilos, the allowable amount of aspartame would be 2,400 milligrams (40 mg/kg x 60 kg). In recent years, several studies have been carried out on the effects of aspartame on health. The Food and Drug Administration (FDA) has reviewed the scientific evidence related to the safety of this sweetener five times since its approval in 1981, and has concluded that it remains safe for use. However, it is being studied again. It has an especially important use in low-calorie beverages consumed by children and pregnan

Light Therapy holds promise as a treatment for Alzheimer's Disease

A new article, conducted by Lili Zang and colleagues from Weifang Medical University School of Nursing in Shandong Province, China, discusses a meta-analysis of 15 high-quality trials that investigated the impact of light therapy on individuals with Alzheimer’s disease (AD). The meta-analysis included 598 patients with mild to moderate Alzheimer’s disease, and it covered 15 randomized controlled trials conducted in seven different countries. Those trials were published between 2005 and 2022. Sleep Improvement Light therapy led to significant improvements in several sleep measures. It notably enhanced sleep efficiency, increased interdaily stability, and reduced intradaily variability, all of which are indicators of better sleep quality. Light therapy was associated with a reduction in agitation, depression, and caregiver burden among individuals with Alzheimer’s disease. A significant advantage over usual care was shown in reducing the severity of psychobehavioral symptoms, as assessed

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