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Researchers have conducted a study focusing on specific brain cells called GABRA5 neurons in the lateral hypothalamic area (LHA) of male rats to understand their role in managing obesity.  These neurons have connections to both white and brown fat tissues in the body.  When obese mice had their GABRA5 neurons suppressed, they experienced metabolic impairments and weight gain, whereas reducing the activity of an enzyme called MAO-B in nearby astrocytes led to increased fat burning and less weight gain.  This suggests that these neurons may help prevent fat accumulation, offering potential insights into obesity treatment strategies.  Additionally, brown adipose tissue (BAT) has been associated with lower risks of cardiometabolic diseases, and a drug called KDS2010, which inhibits MAO-B, has shown promise in promoting weight loss and is in Phase 1 clinical trials as a potential obesity treatment.  Read Original Article

A potential therapeutic target for ameliorating insulin resistance Carlos Martínez Sagasta-Medium.com   Insulin resistance is a common issue associated with conditions like metabolic syndrome and type 2 diabetes.It means that your body's cells have difficulty letting in the fuel they need, which can lead to health problems. Recent research has focused on the role of gut microbiota, the bacteria in our digestive tract, in insulin resistance. These bacteria can impact how our bodies process carbohydrates and energy intake, which is relevant to conditions like obesity and prediabetes. A study in Nature examined human data and found that insulin resistance is linked to certain carbohydrates in stool samples, which are influenced by how gut bacteria process them. (see more)

Hypnosis as a Tool for Managing Fibromyalgia Pain "Harnessing Hypnosis: A Promising Approach to Tackle Fibromyalgia Pain" Fibromyalgia syndrome (FMS) is a complex condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and emotional challenges. The exact cause of FMS is not fully understood, but there's evidence suggesting a link between childhood/adulthood abuse or neglect and its development. Treating FMS can be difficult due to its resistance to most treatments. However, a recent review suggests that hypnotherapy, a psychological intervention, could be effective in managing FMS pain. This technique aims to reduce pain, fatigue, sleep problems, anxiety, and depression by using hypnosis to address emotional conflicts and unresolved traumas associated with FMS. This non-invasive approach might offer relief to those struggling with fibromyalgia. De Benedittis G. The Challenge of Fibromyalgia Efficacy of Hypnosis in Alleviating the Invisibl

The cognitive effects of the MIND diet - News-Medical.net News-Medical.net Such interventions include the Mediterranean diet and dietary ... linked to slower cognitive decline and lower risk of Alzheimer's disease. Low-Cal vs. Fasting Diets: How Does Each Affect the Microbiome? - USNews.com USNews.com Both groups were offered “behavioral support” designed to improve diet quality and encourage increased physical activity. 7-Day High-Protein Meal Plan for Healthy Aging - EatingWell EatingWell Allen, Props: Julia Bayless, Food Stylist: Ana Kelley ... Though any activity is beneficial for healthy aging, strength training is particularly ... Why You Can't Poop on Weekends, According to a Doctor | livestrong Livestrong "Relaxation can affect the motility of food and waste products through your intestinal tract," Dr. ... Your Physical Activity Habits Are Different.

  Breakthrough Obesity Drugs. Could dieting become obsolete? Carlos Martinez Sagasta In the past 50 years, the prevalence of obesity has tripled. Being significantly overweight increases the chances of developing various health issues like type 2 diabetes, heart disease, and several malignancies. The need for the creation of efficient obesity treatments is growing as obesity rates rise. New hormone-mimicking pharmaceuticals may reduce hunger and encourage weight loss regarding the advancement and possibility of novel treatments for obesity. It may reduce the cause of experiencing emotions of guilt and the stigma associated with being overweight. GLP-1 receptor agonists, which have been biochemically designed to increase potency and have a sustained effect, are successfully used in clinical settings to treat type-2 diabetes. The GLP-1 analogue Semaglutide was initially licensed by the US FDA to treat type 2 diabetes, but was later approved as a medication to treat obesity. In a trial, s

Inhaling Pleasant Scents During Sleep Tied to a Dramatic Boost in Cognition In a small, randomized control trial researchers found that when cognitively normal individuals were exposed to the scent of an essential oil for 2 hours every night over 6 months, they experienced a 226% improvement in memory compared with a control group who received only a trace amount of the diffused scent. Ozempic is in the spotlight but it's just the latest in a long and ... Patients on an endless cycle of dieting and exercise want something more convenient, with a more certain outcome. And doctors, too, want to offer patients effective treatment, and a drug prescription is a workable option given the constraints of appointment times. 5 Ways Jaclyn Smith Loses Weight at 77 "What we put on our bodies shows up on our faces," she told Fox and one way she ensures she gets the nutrients needed is by having a green smoothie every day. Obesity as a Disease of Civilization Nigel Barber Ph.D. on Aug

Four key questions on the new wave of anti-obesity drugs Nature.com Scientists want to know who will benefit most, what the long-term effects might be and whether the treatments will change views on obesity. Researchers and clinicians are excited about the latest wave of drugs for obesity treatment, offering hope for patients and potentially changing the perception of obesity.  These medications challenge the notion that obesity results from a lack of willpower, as they target the brain's role in regulating eating behavior.  The hope is that a better understanding of the biological basis of obesity will convince insurers to cover these drugs.  However, some experts express concerns about the potential negative effects, such as exacerbating eating disorders and weight stigma.  The drugs are being introduced into a society with pervasive diet culture and pressure to be slim, highlighting the need for a more nuanced view of health that is independent of weight.  Notably, a study found